PUBLISHED WORK

van der Wagen L.E., Janssen A., Miranda-Bedate  A., Fernando F., Appukudige N., van Dooremalen S., Westinga K., Admiraal R., Lorenowicz M.J., Huls G, Janssen J., Broers A.E.C., van der Velden W.J.F.M., van Marwijk Kooy R., Hazenberg M.D., de Haar C., Lindemans C., Boelens J.J., Kuball J. Efficacy of MSC for steroid refractory acute GVHD associates with MSC donor age and a defined molecular profile. Bone marrow transpl. 2020  Nov;55(11):2188-2192. DOI: 10.1038/s41409-020-0910-9 . IF: 4.67 #Citations: 7

Varderidou-Minasian S. and Lorenowicz M.J. Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles In Tissue Repair: Challenges And Opportunities. Theranostics 2020;

DOI: 10.7150/thno.40122 ; IF: 11.56 #Citations: 107

Thery C. et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines– an ISEV position paper. Journal Of Extracellular Vesicles. Vol. 7 , Iss. 1, 2018 DOI: 10.1080/20013078.2018.1535750  IF: 25. 84 #Citations: 4806

Vonk L.A., van Dooremalen S.F.J., Liv N., Klumperman J., Coffer P.J., Saris D.B., Lorenowicz M.J. Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro. Theranostics. 2018 Jan 1;8(4):906-920. DOI: 10.7150/thno.20746 . IF: 11.56 #Citations: 205

Mateescu B., Kowal E.J.K., van Balkom B.W.M., Sabine Bartel S., Buzás E.I., Buck A.H., de Candia P., Chow F.W.N., Das S., Driedonks T.A.P., Fernández-Messina L., Haderk F., Hill A.F., Jones J.C., Van Keuren-Jensen K.R., Lai C.P., Lässer C., di Liegro I., Lunavat T.R., Lorenowicz M.J., Maas S.L.N., Mäger I., Mittelbrunn M., Momma S., Mukherjee K., Nawaz M., Pegtel M.D., Pfaffl M.W., Schiffelers R.S., Tahara H., Théry C., Tosar J.P., Wauben M.H.M., Witwer K.W., Nolte-‘t Hoen E.N.M. Obstacles and opportunities in the functional analysis of extracellular vesicle RNA – an ISEV position paper. Journal of Extracellular Vesicles. Vol. 6 , Iss. 1,2017 DOI: 10.1080/20013078.2017.1286095  IF: 25.84  #Citations: 473

Gomez Puerto, M.C., Vergahen, LP, Braat AK, Lam EW, Coffer PJ, Lorenowicz MJ. Activation of autophagy by FOXO3A regulates reactive oxygen species during osteogenic differentiation of human mesenchymal stem cells. Autophagy. 2016 Oct 2;12(10):1804-1816. DOI: 10.1080/15548627.2016.1203484  IF: 16.02 #Citations: 70

Lener, T., Gimona, M., Aigner, L., Börger, V., Camussi, G., Chaput,N. , Court, F.A., del Portillo, H.A., O’Driscoll, L., Fais, S., Falcon-Perez, J.M., Felderhoff, U.,Fraile, L., Song Gho, Y., Gupta, R.C., Hendrix, A., Hermann, D.M., Hill, A.F., Hochberg, F., Horn, P.A., de Kleijn, D., Kordelas, L., Kramer, B.W., Krämer-Albers, E.M., Laner-Plamberger, S., Laitinen, S., Leonardi, T., Lorenowicz, M.J., Lim, S.K., Lötvall, J., Maguire, C.A., Nazarenko, I., Ochiya, T., Patel, T., Pederson, S., Pocsfalvi, G.K., Pluchino, S., Quesenberry, P., Reischl, I.G., Rivera, F.J., Sanzenbacher, R., Schallmoser, K., Slaper-Cortenbach, I., Strunk, D., Tonn,T., Vader, P., van Balkom,B.W.M., Wauben, M., EL Andaloussi, S., Théry, C., Rohde, E. and Giebel, B. Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper. J Extracell Vesicles. 2015 Dec 31;4:30087. doi: 10.3402/jev.v4.30087. eCollection 2015. DOI: 10.3402/jev.v4.30087  IF: 25.84 #Citations: 837

de Groot R.E.A., Rappel S.B., Lorenowicz M.J. and C. Korswagen H.C. Protein kinase CK2 is required for Wntless internalization and Wnt secretion. Cell Signal. Dec;26(12):2601-5. Epub 2014 Aug 27. DOI: 10.1016/j.cellsig.2014.08.016  IF: 4.3 # Citations: 11

Lorenowicz MJ, Macurkova M, Harterink M, Middelkoop T, de Groot R, Betist MC, Korswagen HC. Inhibition of late endosomal maturation restores Wnt secretion in Caenorhabditis elegans vps-29 retromer mutants. Cell Signal. 2014 Jan;26(1):19-31. Epub 2013 Sep 20. DOI: 10.1016/j.cellsig.2013.09.013  IF: 4.3 # Citations: 19

Harterink M, Lorenowicz MJ*, Port F*, McGough IJ*, Silhankova M, Betist MC, van Weering JRT, van Heesbeen RGHP, Middelkoop T, Basler K, Cullen PJ, Korswagen HC. A SNX3-dependent Retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. Nat Cell Biol. 2011 13(8): 914-23. DOI: 10.1038/ncb2281 * Equal contribution; IF: 28.82 # Citations: 241

Lorenowicz MJ, Korswagen HC. Sailing with the Wnt: charting the Wnt processing and secretion route. Exp Cell Res. 2009 315:2683-9. DOI: 10.1016/j.yexcr.2009.06.015   IF: 3.5 # Citations: 34

Lorenowicz MJ, Fernandez-Borja M, Kooistra MR, Bos JL, Hordijk PL. PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol. 2008 87:779-92. DOI: 10.1016/j.ejcb.2008.05.004  IF: 4.49  # Citations: 59

Lorenowicz MJ*, Yang PT*, Silhankova M, Coudreuse DY, Betist MC, Korswagen HC. Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells. Dev Cell. 2008 14:140-7. DOI: 10.1016/j.devcel.2007.12.004 * Equal contribution; IF: 12.27 # Citations: 191

Lorenowicz MJ, Fernandez-Borja M, van Stalborch AM, van Sterkenburg MA, Hiemstra PS, Hordijk PL. Microtubule dynamics and Rac-1 signaling independently regulate barrier function in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 293:L1321-31. DOI: 10.1152/ajplung.00443.2006 IF: 5.46 # Citations: 17

Lorenowicz MJ, Fernandez-Borja M, Hordijk PL. cAMP signaling in leukocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 2007 27:1014-22. Review. DOI: 10.1161/ATVBAHA.106.132282  IF: 8.3 # Citations: 72

Lorenowicz MJ, van Gils J, de Boer M, Hordijk PL, Fernandez-Borja M. Epac1-Rap1 signaling regulates monocyte adhesion and chemotaxis. J Leukoc Biol. 2006 80:1542-52; DOI: 10.1189/jlb.0506357 IF: 4.96; #Citations: 85